CRISPulator: a discrete simulation tool for pooled genetic screens

Abstract Background The rapid adoption of CRISPR technology has enabled biomedical researchers to conduct CRISPR-based genetic screens in a pooled format.The quality of results from such screens is heavily dependent on the selection of optimal screen design parameters, which also affects cost and scalability.However, the cost and effort of implemen

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Hermann Rorschach: From klecksography to psychiatry

ABSTRACT Hermann here Rorschach was a Swiss psychiatrist and psychoanalyst, best known for developing a projective test known as the Rorschach inkblot test, a test designed to reflect unconscious parts of the personality that project into the visual stimuli generated by the inkblots, allowing a psychodiagnosis to be established.The technique he dev

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The Importance of the Dissociation Rate in Ion Channel Blocking

Understanding the relationships between the rates and dynamics of current wave forms under voltage clamp conditions is essential for understanding phenomena such as state-dependence and use-dependence, which are fundamental for the action of drugs used as anti-epileptics, anti-arrhythmics, and anesthetics.In the present study, we mathematically ana

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Prophylactic AEDs Treatment for Patients With Supratentorial Meningioma Does Not Reduce the Rate of Perioperative Seizures: A Retrospective Single-Center Cohort Study

Meningiomas, the most common brain tumor, inevitably require surgical treatment.However, the efficacy of prophylactic antiepileptic drugs (AEDs), in reducing the frequency of new-onset seizures during the perioperative period remains controversial.To further clarify if prophylactic antiepileptic drug treatment for patients with usc trojans snapback

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